GHK-Cu (100mg)

Quick Start Highlight

GHK-Cu stands for glycyl-L-histidyl-L-lysine bound to copper (II) — a naturally occurring tripeptide complex first identified in human plasma in the 1970s. It is found throughout the body in blood, saliva, and urine, but its levels decline significantly with age. At age 20, concentrations are much higher than they are by age 60, which correlates with slower healing, reduced skin quality, and diminished hair health.

Unlike drugs that target a single pathway, GHK-Cu acts as a bioregulatory molecule, supporting a wide range of cellular processes. Its main functions include:

• Wound healing and tissue repair – accelerates skin recovery and reduces scarring.

• Collagen and elastin synthesis – strengthens the extracellular matrix that supports both skin and hair follicles.

• Anti-inflammatory signaling – lowers damaging cytokines that contribute to follicle miniaturization and scalp irritation.

• Antioxidant defense – enhances natural protection against oxidative stress, a major factor in aging and hair loss.

• Gene expression modulation – influences thousands of genes related to growth, repair, and metabolic regulation.

Because of these properties, GHK-Cu has been widely studied in dermatology and regenerative medicine. More recently, its ability to stimulate hair follicles, improve scalp circulation, and create a healthier growth environment has made it a promising candidate for hair restoration.

Benefits of GHK-Cu

1. Skin Rejuvenation & Anti-Aging

One of the strongest effects.

• Increases collagen production

• Improves elastin, glycosaminoglycans, and skin thickness

• Reduces fine lines & wrinkles

• Tightens and firms skin

• Improves texture and hydration

• Helps with hyperpigmentation

GHK-Cu is widely used in anti-aging serums for this reason.

2. Wound Healing & Tissue Repair

GHK-Cu speeds tissue repair by:

• Stimulating new blood vessel formation

• Reducing inflammation

• Enhancing fibroblast activity

• Improving skin regeneration

It is used for:

• burns

• scars

• ulcers

• post-procedure healing

3. Anti-Inflammatory Effects

GHK-Cu suppresses certain inflammatory cytokines and helps calm irritated or damaged tissue.

4. Hair Growth & Hair Follicle Strength

GHK-Cu may:

• improve scalp circulation

• reduce follicle inflammation

• extend anagen (growth phase)

It is frequently used in hair-growth formulations.

5. Antioxidant & Anti-Glycation Benefits

GHK-Cu protects cells from oxidative stress and prevents glycation-related skin aging (a process that makes collagen stiff and weak).

6. May Support Nerve & Organ Repair (Early Research)

Preclinical studies show possible benefits in:

• nerve regeneration

• lung repair

• liver protection

These areas are still being researched — not established treatments.

7. Improves Overall Cell Signaling

GHK-Cu activates multiple gene pathways involved in:

• repair

• regeneration

• anti-inflammation

• detoxification

It behaves like a “reset” signal for aging or damaged cells.

How Does GHK-Cu Work?

GHK-Cu is a signal peptide.
It tells your cells to repair, regenerate, and reduce inflammation.

It attaches to copper ions and delivers them into cells — triggering healing and collagen-building pathways.

Stimulates Collagen & Skin Matrix Repair

activates fibroblasts to produce:

• Collagen I & III

• Elastin

• Glycosaminoglycans (like hyaluronic acid)

• Proteoglycans

This improves:

• wrinkles

• skin texture

• firmness

• hydration

Boosts Wound Healing

promotes healing by:

• attracting immune cells to the injury site

• stimulating new blood vessel formation (angiogenesis)

• improving cell migration

• reducing inflammation in damaged tissue

This is why it’s used for:

• scars

• burns

• post-procedure healing

Acts as a Potent Anti-Inflammatory Molecule

downregulates inflammatory genes and upregulates repair genes.
It lowers cytokines like:

• TNF-α

• IL-6

This creates a healthier environment for skin and tissue regeneration.

Strong Antioxidant & Protects Cells

• neutralizes free radicals

• protects cells from oxidative stress

• helps DNA repair

• reduces glycation (which makes collagen stiff and aged)

This slows visible signs of aging.

Delivers Copper Into Cells (Copper Transport Function)

essential for:

• collagen production

• antioxidant enzymes (like SOD)

• angiogenesis

But free copper is toxic.
GHK safely binds and transports copper exactly where it’s needed.

Promotes Hair Growth

stimulates hair follicles by:

• increasing scalp blood flow

• reducing follicular inflammation

• extending the anagen (growth) phase

• increasing size of hair follicles

This is why it's used in hair serums and scalp treatments.

Regulates Gene Expression

One of its most important actions:

GHK-Cu switches on hundreds of genes related to:

• repair

• regeneration

• anti-inflammation

• cell survival

…and switches off genes related to:

• inflammation

• tissue breakdown

• oxidative damage

This “youthful gene reset” effect is a major reason it’s popular in anti-aging science.

Works by:

✔ repairing skin matrix (collagen, elastin)

✔ reducing inflammation

✔ accelerating healing

✔ delivering copper safely into cells

✔ protecting cells from oxidative stress

✔ improving blood flow & tissue oxygenation

✔ activating gene pathways for repair and regeneration

✔ strengthening hair follicles

Potential Side Effects

• Bruising or injection-site pain

• Lumps or nodules

If injected too superficially or in the same area repeatedly.

• Systemic copper increase (rare)

High or frequent doses may raise copper levels, which could cause:

• nausea

• metallic taste

• headache

• fatigue

• digestive discomfort

• Hypotension or dizziness

Very uncommon, but possible if blood vessel dilation occurs.

• Allergic reactions

Symptoms may include:

• swelling

• hives

• rapid heartbeat

• breathing trouble (very rare)

Any severe symptoms require immediate medical attention.

Dosing & Reconstitution Guide

Educational guide for reconstitution and weekly dosing