IGF-1-LR3 (1mg)

Quick Start Highlight

IGF-1 LR3 (Insulin-like Growth Factor 1 Long Arg3) is a synthetic variant of human IGF-1, modified to increase both its potency and half-life. While natural IGF-1 has a very short duration of action (~15–20 minutes), IGF-1 LR3 remains active for up to 20–30 hours, significantly enhancing its biological availability and effect on muscle tissue.

IGF-1 is the primary mediator of HGH's anabolic effects, but unlike HGH — which must first be converted by the liver into IGF-1 — IGF-1 LR3 acts directly on skeletal muscle, promoting:

• Satellite cell activation

• Muscle fiber hypertrophy

• Accelerated tissue repair

• Increased glucose and amino acid uptake

What makes LR3 unique is its low affinity for IGF-binding proteins (IGFBPs), which typically limit the action of natural IGF-1. This resistance allows LR3 to remain unbound and active in circulation for longer durations.

Unlike HGH, which initiates a hormonal cascade, IGF-1 LR3 bypasses the liver and provides localized anabolic effects in muscle, making it especially attractive for those focused on lean mass gains, recovery, and nutrient partitioning.

Because of its direct action, IGF-1 LR3 is often used in short cycles post-workout or during cutting phases when muscle preservation is crucial.

Benefits of IGF-1 LR3

IGF-1 LR3 is one of the most anabolically potent peptides used in performance enhancement due to its direct effect on muscle tissue and prolonged half-life. Unlike HGH, which requires liver conversion to exert muscle-building effects, IGF-1 LR3 acts locally and immediately on skeletal muscle, making it highly efficient for growth, repair, and recovery.

Muscle Hypertrophy and Cell Proliferation

• IGF-1 LR3 stimulates satellite cell activation — the foundation of muscle fiber growth. This promotes new muscle cell formation and enlarges existing fibers, leading to significant hypertrophy when combined with resistance training.

Enhanced Recovery and Tissue Repair

• IGF-1 LR3 accelerates repair of damaged muscle, tendons, and ligaments, shortening recovery time between sessions. It is especially beneficial post-injury or during high-frequency training cycles.

Nutrient Partitioning and Glycogen Replenishment

• IGF-1 LR3 increases cellular uptake of glucose, amino acids, and creatine, improving muscle fullness and recovery. This makes it highly synergistic with carbohydrate refeeding and intra-workout nutrition.

Stack Synergy and Performance Amplification

Because of its direct, local action, IGF-1 LR3 is often stacked with anabolic steroids, HGH, or insulin to amplify protein synthesis and lean tissue gains. It is typically used in short bursts to avoid desensitization.

How Does IGF-1 LR3 Work?

Direct Muscle Growth Stimulator

IGF-1 LR3 binds directly to IGF-1 receptors on muscle fibers, triggering:

• Muscle cell differentiation and proliferation

• Activation of satellite cells, essential for muscle repair and new muscle fiber growth

• Enhanced nutrient uptake (glucose, amino acids, creatine)

Because of this direct action, IGF-1 LR3 can stimulate local muscle hypertrophy without relying on systemic conversion pathways.

Potential Side Effects

Hypoglycemia
IGF-1 has insulin-like properties and can reduce blood sugar levels, especially when combined with insulin or carb restriction.

• Organ and Gut Growth (with misuse)
  Prolonged or high-dose use may lead to non-specific cell growth in internal organs or the intestines, contributing to the "roid gut" or distended abdomen effect seen in some bodybuilders.

• Joint and Muscle Pain
  Some users experience stiffness or tightness in muscles and joints, especially if hydration and electrolyte balance are not maintained.

Desensitization and Diminished Effects
IGF-1 receptor downregulation can occur with chronic use, diminishing results over time and increasing the need for cycling or periodization.

Dosing & Reconstitution Guide

Educational guide for reconstitution and weekly dosing