MOTS-C (10mg)

Quick Start Highlight

MOTS-c is a mitochondrial-derived peptide (MDP) that’s quickly gaining attention in the worlds of longevity, fat loss, insulin regulation, and athletic performance. Unlike most peptides that originate from nuclear DNA, MOTS-c is encoded within the mitochondria, offering unique metabolic effects at the cellular energy level. 

Mitochondrial Origin = Metabolic Power

Unlike typical peptides, MOTS‑c is synthesized in response to cellular energy demands—particularly when glucose is scarce or when the body is under stress. Its primary mechanism is activating AMPK (AMP-activated protein kinase), a master regulator of cellular energy.

• AMPK activation = increased glucose uptake and fat oxidation

• Downregulates anabolic processes that consume ATP

• Promotes mitochondrial biogenesis and cellular resilience

Natural Expression and Peptide Supplementation

Your body naturally produces MOTS‑c, particularly during fasting or exercise. However, exogenous administration (via peptide injection) amplifies these effects—especially in cases of metabolic dysfunction, aging, or intense training.

• Supports mitochondrial health and stress tolerance

• Reduces fat accumulation while improving glucose disposal

• Acts systemically but also targets muscle, liver, and fat cells

Improves Insulin Sensitivity and Glucose Regulation

MOTS‑c increases the translocation of GLUT4 (glucose transporter) to muscle cells, enhancing glucose uptake without needing insulin spikes. 

• Supports metabolic flexibility in both fasted and fed states

•  Useful for individuals with insulin resistance or post-cycle metabolic slowdown

•  May complement fasting, low-carb, strategies for performance athletes

Promotes Fat Loss Without Muscle Breakdown

By activating AMPK and mitochondrial uncoupling, MOTS‑c encourages the body to burn fat more efficiently—especially during caloric restriction or training.

• Reduces visceral and subcutaneous fat

• Enhances fatty acid oxidation and lipolysis

• Preserves lean muscle mass during cut phases

Boosts Endurance and Exercise Capacity

MOTS‑c has been shown to increase aerobic performance by enhancing mitochondrial capacity and sparing glycogen during prolonged exercise.

• More fat burned = glycogen spared = longer time to fatigue

• Especially beneficial for CrossFit, endurance athletes, and metabolic conditioning

Supports Anti-Aging and Stress Resistance

Emerging research suggests that MOTS‑c acts like a mitochondrial stress hormone, improving longevity pathways similar to caloric restriction.

• Activates FoxO transcription factors (linked to stress resilience)

• Enhances mitochondrial autophagy (mitophagy)

• May protect against oxidative damage and aging-related decline

What makes MOTS-C unique?

MOTS‑c offers a unique set of benefits by targeting the mitochondrial control center of energy production, insulin sensitivity, and fat metabolism. Its primary appeal lies in its ability to optimize fuel usage at the cellular level—making it highly relevant for fat loss, endurance, and aging.

How does MOTS-C work?

MOTS‑c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded by mitochondrial DNA (mtDNA), not nuclear DNA like most hormones and peptides. It plays a central role in metabolic homeostasis, helping regulate glucose metabolism, fatty acid oxidation, and cellular stress response. 

Potential Side Effects

Injection site irritation: Redness, swelling, or slight bruising at subcutaneous sites

• Mild fatigue or lethargy: Especially when first adjusting to mitochondrial AMPK activation

• Hunger changes: Some users report appetite suppression, while others feel more hungry due to enhanced fat mobilization

• Muscle cramping: Rare, possibly due to increased fatty acid metabolism and electrolyte shift

Dosing & Reconstitution Guide

Educational guide for reconstitution and weekly dosing